Another word from “The Dancing Men” in The Greatest Adventures of Sherlock Holmes is “Nettled”. The context made me believe the word must mean something like perturbed, and I was not wrong.

Nettled – irritated or annoyed

Usage: After stating that he would not call Holmes’ methods simple once explained, Dr Watson still cried, “How absurdly simple!”

“Quite so!” said [Holmes], a little nettled. “Every problem becomes very childish when once it is explained to you.”