I found this word in The Valley of Fear, in my volume, The Greatest Adventures of Sherlock Holmes. I don’t think I’ve ever heard it before, but the context made me think it meant something like the lowest of the low. I wasn’t too far off.

Opprobrium – the disgrace or reproach incurred by shameful conduct; the cause of such disgrace

Usage: This is from a newspaper article which described the “Reign of Terror” the lodge had brought on those living in Vermissa Valley. “From that day these outrages have never ceased, until now they have reached a pitch which makes us the opprobrium of the civilized world.” If you read my post about The Valley of Fear, you will remember that this newspaper article , and the outrages mentioned, took place about twenty years before Sherlock Holmes ever began investigating the case.